Ascorbic acid (Vitamin C) is a water soluble vitamin readily absorbed from the gastrointestinal tract. Ascorbic acid prevents biological oxidation hence it is called antioxidant. It protects cells against damage by free radicals, which are reactive by-products of normal cell activity. Ascorbic acid helps produce collagen, a protein needed to develop and maintain healthy teeth, bones, gums, cartilage, vertebrae discs, joint linings, skin and blood vessels. Deficiency of vitamin C develops scurvy characterized by spongy and bleeding gums, bleeding under the skin, and extreme weakness. Symptoms may include irritability, depression, weight loss, fatigue, and general weakness. The gums become swollen, purple, and spongy. The teeth eventually loosen. Infections may develop, and wounds do not heal. Ascorbic acid supplementation is required for the prevention and treatment of scurvy and the deficiency symptoms.
Chewce Tablet : Each chewable tablet contains Ascorbic acid BP 250 mg.
Chewce Syrup : Each 5 ml syrup contains Ascorbic acid BP 100 mg.
Ascorbic acid is indicated for the prevention and treatment of scurvy. It may also indicated in healing cuts, abrasion and wounds; fight against infections; to inhibit conversion of irritants in smog, tobacco smoke, and certain foods into cancer causing substances, to dilate (widen, enlarge) blood vessels and thereby lessen the risk of developing high blood pressure and heart disease, to help regulate cholesterol levels, to lower the risk of developing cataracts, clouding of the lens of the eye that impairs vision, to protect diabetics against deterioration of nerves, eyes and kidneys, to help in early brain development of children.
For the treatment of scurvy: 1-2 tablets daily; but dose may be increased depending on the severity of the condition.
For the reduction of risk of stroke in the elderly: 1-2 tablets daily.
In other cases: 1 tablet daily or as prescribed by the physician.
2 to 6 years - 5 ml (1 TSP)
7 to 12 years - 10 ml (2 TSPS) or as prescribed by the physician.
Maximum safe dose is 2000 mg daily in divided doses.
Side Effects :
Relatively large doses of vitamin C may cause indigestion particularly when taken on an empty stomach. Vitamin C toxicity is very rare, because the body cannot store the vitamin. However, amounts greater than 2,000 mg/day are not recommended because such high doses can lead to stomach upset and diarrhea.
Drug Interaction :
Potentially hazardous interactions :
Ascorbic acid is incompatible in solution with aminophylline, bleomycin, erythromycin, lactobionate, nafcillin, nitrofurantoin sodium, conjugated oestrogen, sodium bicarbonate, sulphafurazole diethanolamine, chloramphenicol, sodium succinate, chlorthiazide sodium and hydrocortisone sodium succinate.
Useful interactions :
Ascorbic acid increases the apparent half-life of paracetamol and enhances
iron absorption from the gastrointestinal tract.
Use in Pregnancy and Lactation :
The drug is safe in normal doses in pregnant women, but a daily intake of 5 gm or more is reported to have caused abortion.
The drug may be taken safely during lactation.
Commercial Supply :
Chewce Tablet : Each box contains 20 x 10's tablets in alu alu strip pack.
Chewce Syrup 60 ml : Each bottle contains 60 ml syrup.
Chewce Syrup 100 ml : Each bottle contains 100 ml syrup.